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Our Approach

Gelesis100 is a first-in-class therapeutic that is designed to treat the physiological symptoms of hunger without surgery, other invasive procedures or systemically absorbed drugs. It is designed to safely cause significant weight loss.




Gelesis100 is designed to trigger several important weight loss mechanisms in the stomach and small intestine. The product is a highly engineered and proprietary patented hydrogel whose components are materials with Generally Recognized as Safe (GRAS) designation. We believe Gelesis100 represents a breakthrough in material science and has been designed and finely tuned to act in specific ways throughout the gastrointestinal tract (see below):




Our Technology


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Gelesis100 capsules administered with water prior to a meal

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Particles released & expand in stomach by absorbing water



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Particles mix homogenously with food and designed to enhance satiety due to increased volume & elasticity of stomach contents

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Increased elasticity of stomach contents designed to delay gastric emptying as stomach contents flow into small intestine



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Particles designed to create a diffusion barrier that slows absorption of glucose in small intestine

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Particles partially degrade in the large intestine, water is released & reabsorbed by body, and particles are eliminated from body

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Other Approaches

Obesity therapies have historically been hampered by one or more of the following challenges:

  •    Adverse events or side effects that limit dose

  •    Substantial safety vs. efficacy tradeoffs

  •    Invasive procedures or less desirable administration routes such as injections


Typical Side Effects of Other Approaches


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Prescription
Weight Loss Drugs

  • High Abuse Potential
  • Anxiety
  • Dry Mouth
  • Constipation
  • Insomnia
  • Increased Blood Pressure & Heart Rate
  • Lightheadedness
  • Oily Spotting
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Devices & Minimally
Invasive Surgery

  • Nausea
  • Internal Bleeding
  • Implant Slippage
  • Device May Need Adjustment
  • Gallstones
  • Infections
  • Pulmonary Embolism
  • Death
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Gastric Bypass
Surgery

  • Blood Clots
  • Dumping Syndrome
  • Loss of Bodily Function
  • Nutrition Deficiencies
  • Internal Bleeding
  • Infections
  • Depression
  • Death