We believe we can empower people to improve and change their diet, lifestyle and health.

Gelesis is a biotechnology company developing a novel category of therapies for GI-related chronic diseases.
Our superabsorbent hydrogels mimic some of the properties of raw vegetables. They are conveniently administered in capsules and act locally in the stomach and intestines. They increase the volume and firmness of the foods we eat while reducing the caloric density of meals.

Our portfolio includes an FDA cleared product to aid in weight management, as well as potential therapies in development for Type 2 Diabetes, Non-alcoholic Fatty Liver Disease (NAFLD)/Non-alcoholic Steatohepatitis (NASH), and Functional Constipation.


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Plenity® is FDA-cleared to aid in weight management in adults with excess weight or obesity, Body Mass Index (BMI) of 25 to 40 kg/m², when used in conjunction with diet and exercise.
In clinical trials, side effects with PLENITY® were similar to placebo (sugar pill). The most common side effects were diarrhea, distended abdomen, infrequent bowel movements and flatulence. Instructions for use

“We are thrilled to be able to bring this new approach to the millions of people looking for a safe, validated and convenient approach to manage their weight without surgery or stimulants.”

A novel hydrogel technology platform

Our hydrogel is designed to mimic some of the effects of eating raw vegetables.

The proprietary Gelesis platform is the first and only superabsorbent hydrogel made exclusively from naturally-derived building blocks.